Interactions of the Platinum(II) Complexes with Nitrogen- and Sulfur-Bonding Bio-Molecules in Chronic Lymphocytic Leukemia

Transition metals and their reactions are in general important in the environment, in technical processes (catalysis, extraction and purification of metal complexes) and in biology and medicine (biological electron transfer, toxicology and use of metal complexes as drugs). Moreover, nonessential metal ions are very often used in biological systems either for therapeutic application or as diagnostic aids. For instance, metal complexes have been used for the treatment of many diseases (cancer, arthritis, diabetes, Alzheimer, etc.), but with little understanding of their mechanism of action in biological systems.(Ronconi & Sadler, 2007; Bruijnincx & Sadler, 2009) Biochemical studies have not clearly established the molecular basis for the activity and mechanism of action. The growing field of bioinorganic chemistry is presently dealing with the clarification of the mechanisms of action of metal complexes in biological systems.(Ronconi & Sadler,2007; Bruijnincx & Sadler, 2009; Jakupec et al., 2008)